Disrupted Core Periphery of Brain Networks in Multiple Sclerosis
UCL Queen Square Institute of Neurology, University College London
2024
n=1484
publication
Evidence: high
Pontillo Giuseppe, Prados Ferran, Wink Alle Meije, Kanber Baris, Bisecco Alvino, Broeders Tommy A. A., Brunetti Arturo, Cagol Alessandro, Calabrese Massimiliano, Castellaro Marco, Cocozza Sirio, Colato Elisa, Collorone Sara, Cortese Rosa, De Stefano Nicola, Douw Linda, Enzinger Christian, Filippi Massimo, Foster Michael A., Gallo Antonio, Gonzalez‐Escamilla Gabriel, Granziera Cristina, Groppa Sergiu, Harbo Hanne F., Høgestøl Einar A., Llufriu Sara, Lorenzini Luigi, Martinez‐Heras Eloy, Messina Silvia, Moccia Marcello, Nygaard Gro O., Palace Jacqueline, Petracca Maria, Pinter Daniela, Rocca Maria A., Strijbis Eva, Toosy Ahmed, Valsasina Paola, Vrenken Hugo, Ciccarelli Olga, Cole James H., Schoonheim Menno M., Barkhof Frederik
Title
Disrupted Core Periphery of Brain Networks in Multiple Sclerosis
Hypothesis
Joint brain network changes across structural and functional levels would manifest in a disrupted multilayer core-periphery structure compared to healthy individuals.
Conclusion
The study shows that multilayer networks represent a meaningful framework to model multimodal MRI data, with disruption of the core-periphery structure emerging as a potential biomarker for disease severity and cognitive impairment in multiple sclerosis.