PubSort

Pubsort is a free search engine for publications that pre-summarizes each paper’s key findings, hypothesis, conclusion, and supporting evidence.

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Recent Publications

Detecting Methylation in Serum for Gastric Cancer Diagnosis

The Chinese University of Hong Kong 2005 n=60 publication Evidence: moderate

Leung W K, To K-F, Chu E S H, Chan M W Y, Bai A H C, Ng E K W, Chan F K L, Sung J J Y

Title

Detecting Methylation in Serum for Gastric Cancer Diagnosis

Hypothesis

Can detecting promoter hypermethylation in the serum of gastric cancer patients provide diagnostic and prognostic value?

Conclusion

The study found that detecting DNA methylation in the serum may help diagnose and predict outcomes in gastric cancer patients.

Impact of bgsB Deletion on Enterococcus faecalis

Center for Infectious Diseases and Travel Medicine, University Medical Center Freiburg, Germany 2011 n=8 publication 10 minutes Evidence: high

Theilacker Christian, Sava Irina, Sanchez-Carballo Patricia, Bao Yinyin, Kropec Andrea, Grohmann Elisabeth, Holst Otto, Huebner Johannes

Title

Impact of bgsB Deletion on Enterococcus faecalis

Hypothesis

The gene bgsB is responsible for the glycosylation of diacylglycerol to form monoglucosyldiacylglycerol.

Conclusion

Deletion of bgsB leads to a complete loss of glycolipids from the cell membrane, impairing biofilm formation and virulence.

AI and Machine Learning in Antibiotic Dose Prediction

Health Research Institute of Santiago de Compostela (IDIS) 2024 n=13 publication Evidence: moderate

Iria Varela-Rey, Enrique Bandín-Vilar, Francisco José Toja-Camba, Antonio Cañizo-Outeiriño, Francisco Cajade-Pascual, Marcos Ortega-Hortas, Víctor Mangas-Sanjuan, Miguel González-Barcia, Irene Zarra-Ferro, Cristina Mondelo-García, Anxo Fernández-Ferreiro, Yukihiro Hamada

Title

AI and Machine Learning in Antibiotic Dose Prediction

Hypothesis

The application of AI and machine learning techniques can improve pharmacokinetic modeling and dose prediction of antibiotics.

Conclusion

AI techniques show promising results in pharmacokinetic modeling, but their effectiveness compared to classical methods is still uncertain.

Mycobacterium tuberculosis genetic diversity and classification

Institut Pasteur de Guadeloupe 2006 n=39295 publication Evidence: high

Brudey Karine, Driscoll Jeffrey R, Rigouts Leen, Prodinger Wolfgang M, Gori Andrea, Al-Hajoj Sahal A, Allix Caroline, Aristimuño Liselotte, Arora Jyoti, Baumanis Viesturs, Binder Lothar, Cafrune Patricia, Cataldi Angel, Cheong Soonfatt, Diel Roland, Ellermeier Christopher, Evans Jason T, Fauville-Dufaux Maryse, Ferdinand Séverine, de Viedma Dario Garcia, Garzelli Carlo, Gazzola Lidia, Gomes Harrison M, Guttierez M Cristina, Hawkey Peter M, van Helden Paul D, Kadival Gurujaj V, Kreiswirth Barry N, Kremer Kristin, Kubin Milan, Kulkarni Savita P, Liens Benjamin, Lillebaek Troels, Ly Ho Minh, Martin Carlos, Martin Christian, Mokrousov Igor, Narvskaïa Olga, Ngeow Yun Fong, Naumann Ludmilla, Niemann Stefan, Parwati Ida, Rahim Zeaur, Rasolofo-Razanamparany Voahangy, Rasolonavalona Tiana, Rossetti M Lucia, Rüsch-Gerdes Sabine, Sajduda Anna, Samper Sofia, Shemyakin Igor G, Singh Urvashi B, Somoskovi Akos, Skuce Robin A, van Soolingen Dick, Streicher Elisabeth M, Suffys Philip N, Tortoli Enrico, Tracevska Tatjana, Vincent Véronique, Victor Tommie C, Warren Robin M, Yap Sook Fan, Zaman Khadiza, Portaels Françoise, Rastogi Nalin, Sola Christophe

Title

Mycobacterium tuberculosis genetic diversity and classification

Hypothesis

Co-evolution between human beings and bacilli, and vertical transmission must have been the main mode of tuberculosis transmission throughout centuries.

Conclusion

The SpolDB4 database broadens the understanding of the global phylogeography of the Mycobacterium tuberculosis complex.

Capecitabine and Docetaxel for Metastatic Oesophageal Cancer

Technical University of Munich 2005 n=24 publication Evidence: moderate

Lorenzen S, Duyster J, Lersch C, von Delius S, Hennig M, Bredenkamp R, Peschel C, Lordick F

Title

Capecitabine and Docetaxel for Metastatic Oesophageal Cancer

Hypothesis

This trial assessed the efficacy, safety and feasibility of capecitabine in combination with docetaxel in patients with metastatic oesophageal cancer.

Conclusion

Capecitabine plus docetaxel has a manageable adverse event profile and promising activity in metastatic oesophageal cancer.

Calcium and Phosphorus Digestibility in Broiler Feed Ingredients

University of Pretoria 2024 n=1700 publication 10 minutes Evidence: high

Venter Kyle Marcus, Angel Roselina, Fourie Jamie, Plumstead Peter William, Li Wenting, Enting Henk, Dersjant-Li Yueming, Jansen van Rensburg Christine

Title

Calcium and Phosphorus Digestibility in Broiler Feed Ingredients

Hypothesis

This study aims to determine the standardized ileal digestibility (SID) of calcium and phosphorus from various plant-based feed ingredients with and without phytase supplementation.

Conclusion

The study provides standardized digestibility values for calcium and phosphorus from selected feed ingredients, highlighting the importance of phytase in improving nutrient availability.

Plakoglobin and Bladder Cancer

Robert E Wise MD Research and Education Institute 2005 n=12 publication Evidence: moderate

Rieger-Christ K M, Ng L, Hanley R S, Durrani O, Ma H, Yee A S, Libertino J A, Summerhayes I C

Title

Plakoglobin and Bladder Cancer

Hypothesis

What is the role of plakoglobin in bladder tumorigenesis?

Conclusion

Restoration of plakoglobin expression in bladder carcinoma cells reduces migration and tumorigenic potential.

Lateral Gene Transfer of Streptococcal ICE Element RD2

Center for Molecular and Translational Human Infectious Diseases Research, The Methodist Hospital Research Institute 2011 publication Evidence: moderate

Sitkiewicz Izabela, Green Nicole M, Guo Nina, Mereghetti Laurent, Musser James M

Title

Lateral Gene Transfer of Streptococcal ICE Element RD2

Hypothesis

The RD2 element was laterally transferable in vitro under laboratory conditions.

Conclusion

The RD2 element has disseminated by lateral gene transfer to genetically diverse strains of human-pathogenic streptococci.

New Anti-Tumor and Antimicrobial Compounds from Halogenoaminopyrazoles

University of Bucharest 2024 publication 10 minutes Evidence: moderate

Zalaru Christina, Dumitrascu Florea, Draghici Constantin, Ferbinteanu Marilena, Tarcomnicu Isabela, Marinescu Maria, Moldovan Zenovia, Nitulescu George Mihai, Tatia Rodica, Popa Marcela, Franco Carlos M., Dixon Nicholas

Title

New Anti-Tumor and Antimicrobial Compounds from Halogenoaminopyrazoles

Hypothesis

The study aims to synthesize new pyrazole derivatives with potential anti-tumor and antimicrobial activities.

Conclusion

The synthesized compounds showed promising anti-tumor and antimicrobial activities, with some exhibiting high biocompatibility.

hMSH2 and its Role in Estrogen Receptor Activation

Department of Obstetrics and Gynecology, Graduate School of Medicine, The University of Tokyo 2005 publication Evidence: moderate

Wada-Hiraike O, Yano T, Nei T, Matsumoto Y, Nagasaka K, Takizawa S, Oishi H, Arimoto T, Nakagawa S, Yasugi T, Kato S, Taketani Y

Title

hMSH2 and its Role in Estrogen Receptor Activation

Hypothesis

Does the DNA mismatch repair gene hMSH2 interact with estrogen receptors to influence gene expression?

Conclusion

The study suggests that hMSH2 acts as a coactivator for estrogen receptor α, enhancing its transcriptional activity.

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