Kirsten ras mutations in colorectal cancer
Department of Medicine & Therapeutics, Imperial College School of Medicine, Chelsea & Westminster Hospital, London, UK
2001
n=3439
publication
Evidence: high
Andreyev H J N, Norman A R, Cunningham D, Oates J, Dix B R, Iacopetta B J, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes H M, Zietz C, Troungos C, Valavanis C, Yuen S T, Ho J W C, Croke C T, O'Donoghue D P, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, Goeij A F P M de, Arends J W, Andersen S N, Lövig T, Breivik J, Gaudernack G, Clausen O P F, Angelis P De, Meling G I, Rognum T O, Smith R, Goh H-S, Font A, Rosell R, Sun X F, Zhang H, Benhattar J, Losi L, Lee J Q, Wang S T, Clarke P A, Bell S, Quirke P, Bubb V J, Piris J, Cruickshank N R, Morton D, Fox J C, Al-Mulla F, Lees N, Hall C N, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo V E, Finkelstein S D, Thebo J S, Senagore A J, Halter S A, Wadler S, Malik S, Krtolica K, Urosevic N
Title
Kirsten ras mutations in colorectal cancer
Hypothesis
Do different Kirsten ras mutations affect the outcomes of colorectal cancer patients?
Conclusion
The study found that a specific mutation in the Kirsten ras gene significantly impacts survival outcomes in colorectal cancer patients.