Kirsten ras mutations in colorectal cancer
Author Information
Author(s): Andreyev H J N, Norman A R, Cunningham D, Oates J, Dix B R, Iacopetta B J, Young J, Walsh T, Ward R, Hawkins N, Beranek M, Jandik P, Benamouzig R, Jullian E, Laurent-Puig P, Olschwang S, Muller O, Hoffmann I, Rabes H M, Zietz C, Troungos C, Valavanis C, Yuen S T, Ho J W C, Croke C T, O'Donoghue D P, Giaretti W, Rapallo A, Russo A, Bazan V, Tanaka M, Omura K, Azuma T, Ohkusa T, Fujimori T, Ono Y, Pauly M, Faber C, Glaesener R, Goeij A F P M de, Arends J W, Andersen S N, Lövig T, Breivik J, Gaudernack G, Clausen O P F, Angelis P De, Meling G I, Rognum T O, Smith R, Goh H-S, Font A, Rosell R, Sun X F, Zhang H, Benhattar J, Losi L, Lee J Q, Wang S T, Clarke P A, Bell S, Quirke P, Bubb V J, Piris J, Cruickshank N R, Morton D, Fox J C, Al-Mulla F, Lees N, Hall C N, Snary D, Wilkinson K, Dillon D, Costa J, Pricolo V E, Finkelstein S D, Thebo J S, Senagore A J, Halter S A, Wadler S, Malik S, Krtolica K, Urosevic N
Primary Institution: Department of Medicine & Therapeutics, Imperial College School of Medicine, Chelsea & Westminster Hospital, London, UK
Hypothesis
Do different Kirsten ras mutations affect the outcomes of colorectal cancer patients?
Conclusion
The study found that a specific mutation in the Kirsten ras gene significantly impacts survival outcomes in colorectal cancer patients.
Supporting Evidence
- The study analyzed data from 3439 patients after applying exclusion criteria.
- Only one mutation on codon 12 had a statistically significant impact on survival.
- The glycine to valine mutation was found in 8.6% of patients.
- This mutation had a greater impact on patients with Dukes’ C cancers compared to Dukes’ B tumours.
Takeaway
This study looked at how certain gene changes in cancer can affect how well patients do. One specific change was found to be really important for survival.
Methodology
Data from 3439 patients were analyzed using multivariate analysis to assess the impact of Kirsten ras mutations on survival.
Participant Demographics
Patients from 42 centres in 21 countries were included.
Statistical Information
P-Value
P = 0.004
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website