PubSort

Pubsort is a free search engine for publications that pre-summarizes each paper’s key findings, hypothesis, conclusion, and supporting evidence.

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Recent Publications

Prevalence of Lower Extremity Edema After Inguinal Lymphadenectomy

University Medical Center Utrecht 2024 n=2376 publication Evidence: moderate

Hahn Brett A., Richir Milan C., Witkamp Arjen J., de Jong Tim, Krijgh David D.

Title

Prevalence of Lower Extremity Edema After Inguinal Lymphadenectomy

Hypothesis

What is the prevalence of lower extremity lymphedema (LEL) following inguinal lymphadenectomy?

Conclusion

The study found that the prevalence of lower extremity lymphedema following inguinal lymphadenectomy is approximately 24%, with higher rates observed in patients treated for vulvar cancer.

Fish Metagenomes and Overexploitation of Fish

Department of Functional Biology, University of Oviedo, Oviedo, Spain 2011 n=40 publication Evidence: moderate

Ardura Alba, Planes Serge, Garcia-Vazquez Eva

Title

Fish Metagenomes and Overexploitation of Fish

Hypothesis

The study aims to apply a metagenome approach to fish communities to evaluate biodiversity and genetic diversity at the community level.

Conclusion

The Amazonian fish community shows lower metagenomic diversity than expected, likely due to overexploitation.

Understanding Cisplatin Resistance in Ovarian Cancer Cells

The Institute of Cancer Research 1992 publication Evidence: moderate

S.Y. Loh, P. Mistry, L.R. Kelland, G. Abel, K.R. Harrap

Title

Understanding Cisplatin Resistance in Ovarian Cancer Cells

Hypothesis

Reduced drug accumulation is a major mechanism of acquired resistance to cisplatin in ovarian carcinoma cells.

Conclusion

The study found that reduced drug accumulation is a key factor in the acquired resistance to cisplatin in ovarian cancer cells.

Cognitive Therapy for Major Depressive Disorder

Copenhagen University Hospital 2011 n=719 publication Evidence: low

Jakobsen Janus Christian, Lindschou Hansen Jane, Storebø Ole Jakob, Simonsen Erik, Gluud Christian

Title

Cognitive Therapy for Major Depressive Disorder

Hypothesis

What are the beneficial and harmful effects of cognitive therapy versus ‘treatment as usual’ in the treatment of major depressive disorder?

Conclusion

Cognitive therapy might not be an effective treatment for major depressive disorder compared with ‘treatment as usual’, with only a small effect observed.

Achieving a Functional Cure for Chronic Hepatitis B

Peking University People's Hospital, Peking University Hepatology Institute, Beijing, China 2024 n=4769 publication 10 minutes Evidence: moderate

Zheng Jiarui, Wang Zilong, Huang Linxiang, Qiu Zixuan, Xie Yandi, Jiang Suzhen, Feng Bo

Title

Achieving a Functional Cure for Chronic Hepatitis B

Hypothesis

What factors and mechanisms influence the functional cure of chronic hepatitis B?

Conclusion

The study identifies complex factors and mechanisms that affect the functional cure of chronic hepatitis B, providing insights for personalized treatment strategies.

Design and Implementation of a Cardiovascular Gene-Centric SNP Array

Institute for Translational Medicine and Therapeutics, School of Medicine, University of Pennsylvania 2008 n=200000 publication Evidence: high

Brendan J. Keating, Sam Tischfield, Sarah S. Murray, Tushar Bhangale, Thomas S. Price, Joseph T. Glessner, Luana Galver, Jeffrey C. Barrett, Struan F. A. Grant, Deborah N. Farlow, Hareesh R. Chandrupatla, Mark Hansen, Saad Ajmal, George J. Papanicolaou, Yiran Guo, Mingyao Li, Stephanie DerOhannessian, Paul I. W. de Bakker, Swneke D. Bailey, Alexandre Montpetit, Andrew C. Edmondson, Kent Taylor, Xiaowu Gai, Susanna S. Wang, Myriam Fornage, Tamim Shaikh, Leif Groop, Michael Boehnke, Alistair S. Hall, Andrew T. Hattersley, Edward Frackelton, Nick Patterson, Charleston W. K. Chiang, Cecelia E. Kim, Richard R. Fabsitz, Willem Ouwehand, Alkes L. Price, Patricia Munroe, Mark Caulfield, Thomas Drake, Eric Boerwinkle, David Reich, A. Stephen Whitehead, Thomas P. Cappola, Nilesh J. Samani, A. Jake Lusis, Eric Schadt, James G. Wilson, Wolfgang Koenig, Mark I. McCarthy, Sekar Kathiresan, Stacey B. Gabriel, Hakon Hakonarson, Sonia S. Anand, Muredach Reilly, James C. Engert, Deborah A. Nickerson, Daniel J. Rader, Joel N. Hirschhorn, Garret A. FitzGerald

Title

Design and Implementation of a Cardiovascular Gene-Centric SNP Array

Hypothesis

The study aims to create a gene-centric 50 K SNP array to assess genetic loci related to cardiovascular, metabolic, and inflammatory syndromes.

Conclusion

The IBC array provides enhanced coverage of high-priority cardiovascular disease-related loci and facilitates more robust genetic analyses.

Skp2B Overexpression Affects p53 and PAPP-A in Breast Cancer

Mount Sinai School of Medicine, New York, New York, United States of America 2011 publication Evidence: moderate

Chander Harish, Halpern Max, Resnick-Silverman Lois, Manfredi James J., Germain Doris

Title

Skp2B Overexpression Affects p53 and PAPP-A in Breast Cancer

Hypothesis

Is there a link between p53 activity and the proteolysis of IGFBP-4 in breast cancer?

Conclusion

The study reveals that prohibitin acts as a chaperone for p53, and its degradation by Skp2B leads to increased PAPP-A levels and IGFBP-4 cleavage, contributing to breast cancer progression.

Epidemiological Insights into Severe Hepatitis in Pediatric Inpatients

Peking Union Medical College Hospital, Chinese Academy of Medical Sciences 2024 n=34410 publication 10 minutes Evidence: high

Guo Fuping, Ma Xudong, Shan Qijun, Zhang Yuelun, Gao Sifa, Chen Jieqin, Chen Yujie, Liu Dawei, Li Taisheng, Zhang Feng, Zhou Xiang

Title

Epidemiological Insights into Severe Hepatitis in Pediatric Inpatients

Hypothesis

What are the epidemiological characteristics and mortality-related risk factors for children hospitalized with severe hepatitis in mainland China?

Conclusion

The study found that indeterminate causes of severe hepatitis were present in 79% of cases, significantly increasing the risk of in-hospital mortality.

Bone Morphogenetic Proteins in Prostate Cancer

Sheffield University Medical School 1992 n=41 publication Evidence: moderate

H. Bentley, F.C. Hamdy, K.A. Hart, J.M. Seid, J.L. Williams, D. Johnstone, R.G.G. Russell

Title

Bone Morphogenetic Proteins in Prostate Cancer

Hypothesis

Can prostatic tissue express bone morphogenetic proteins (BMPs) and how does their expression relate to benign and malignant conditions?

Conclusion

The study found that BMPs are expressed in both benign and malignant prostate tissues, with BMP-6 being particularly associated with metastatic prostate adenocarcinoma.

Visual Acuity and Its Factors in Central India

Suraj Eye Institute, Nagpur, Maharashtra, India 2011 n=4711 publication Evidence: moderate

Nangia Vinay, Jonas Jost B., Sinha Ajit, Gupta Rajesh, Agarwal Shubhra

Title

Visual Acuity and Its Factors in Central India

Hypothesis

What are the factors associated with visual acuity in a rural population of Central India?

Conclusion

Visual acuity in this rural population is significantly influenced by socioeconomic background, body stature, body mass index, age, refractive error, cataract, and intraocular pressure.

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