Prevalence of Lower Extremity Edema After Inguinal Lymphadenectomy
Author Information
Author(s): Hahn Brett A., Richir Milan C., Witkamp Arjen J., de Jong Tim, Krijgh David D.
Primary Institution: University Medical Center Utrecht
Hypothesis
What is the prevalence of lower extremity lymphedema (LEL) following inguinal lymphadenectomy?
Conclusion
The study found that the prevalence of lower extremity lymphedema following inguinal lymphadenectomy is approximately 24%, with higher rates observed in patients treated for vulvar cancer.
Supporting Evidence
- The pooled prevalence of lower extremity lymphedema was estimated to be 24%.
- Patients undergoing lymphadenectomy for vulvar cancer had a higher prevalence of 30.96%.
- Subgroup analysis showed significant differences in LEL prevalence based on the indication for lymphadenectomy.
Takeaway
After surgery to remove lymph nodes in the groin, about 1 in 4 people might get swelling in their legs, especially if they had surgery for vulvar cancer.
Methodology
This study conducted a systematic review and meta-analysis of 23 studies to estimate the prevalence of lower extremity lymphedema following inguinal lymphadenectomy.
Potential Biases
Some studies had a high risk of bias due to incomplete data on lymphedema prevalence.
Limitations
The study's limitations include the retrospective nature of many included studies and the heterogeneity in definitions and measurement methods for lymphedema.
Participant Demographics
Participants included 2,376 patients aged 23 to 94 years, with various malignancies treated by inguinal lymphadenectomy.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI: 17-31
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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