Mechanism for the increased permeability in endothelial monolayers induced by elastase
1994
How Elastase Affects Blood Vessel Permeability
Sample size: 8
publication
Evidence: moderate
Author Information
Author(s): N. Suzuki, Y. Ishii, S. Kitamura
Primary Institution: Jichi Medical School
Hypothesis
The study investigates the mechanism by which human neutrophil elastase (HNE) increases endothelial permeability.
Conclusion
Elastase increases endothelial permeability mainly through its proteolytic effects.
Supporting Evidence
- HNE increases the permeability of the endothelial monolayer in a concentration dependent manner.
- Heat inactivated HNE did not increase permeability.
- ONO-5046, a specific inhibitor of HNE, completely blocked the HNE induced increase in albumin clearance.
Takeaway
Elastase is a substance that can make blood vessels leakier, which can be important in lung injuries.
Methodology
Bovine pulmonary artery endothelial cells were treated with various concentrations of human neutrophil elastase, and transendothelial albumin clearance was measured.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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