CD10 and Osteopontin in Dentigerous Cyst and Ameloblastoma
Author Information
Author(s): Masloub Shaimaa M, Abdel-Azim Adel M, Abd Elhamid Ehab S
Primary Institution: Ain Shams University, Cairo, Egypt
Hypothesis
To investigate the expression of CD10 and osteopontin in dentigerous cyst and ameloblastoma and to correlate their expression with neoplastic potentiality of dentigerous cyst and local invasion and risk of local recurrence in ameloblastoma.
Conclusion
High CD10 and osteopontin expression may indicate the neoplastic potentiality of certain areas in dentigerous cysts and identify areas with locally invasive behavior and high risk of recurrence in ameloblastoma.
Supporting Evidence
- High CD10 and osteopontin expression was observed in unicystic and multicystic ameloblastoma.
- Low CD10 and osteopontin expression was observed in dentigerous cyst.
- Significant correlation was seen between CD10 and osteopontin expression and neoplastic potentiality of dentigerous cyst.
Takeaway
This study looked at two proteins, CD10 and osteopontin, in cysts and tumors in the mouth to see if they can help predict how aggressive these growths might be.
Methodology
Immunohistochemistry was used to study CD10 and osteopontin expression in 9 cases of dentigerous cysts and 17 cases of ameloblastoma.
Limitations
The study had a small sample size, which may affect the reliability of the results.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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