Whole Grains and Colorectal Cancer Risk
Author Information
Author(s): Larsson S C, Giovannucci E, Bergkvist L, Wolk A
Primary Institution: Karolinska Institutet
Hypothesis
Does high whole grain consumption reduce the risk of colorectal cancer in women?
Conclusion
High consumption of whole grains may decrease the risk of colon cancer in women.
Supporting Evidence
- High consumption of whole grains was associated with a lower risk of colon cancer.
- The multivariate rate ratio of colon cancer for the highest category of whole grain consumption was 0.67.
- After excluding cases occurring within the first 2 years of follow-up, the RR was 0.65.
- Women with high whole grain consumption were older, leaner, and more educated.
Takeaway
Eating a lot of whole grains, like rye bread, can help keep your tummy healthy and lower the chances of getting colon cancer.
Methodology
The study used a food-frequency questionnaire to assess whole grain consumption and linked data with the Swedish Cancer Registry to identify colorectal cancer cases.
Potential Biases
Potential residual confounding from differences in dietary and lifestyle factors among participants.
Limitations
Some measurement error in estimating whole grain consumption may exist, and the study could be influenced by other lifestyle factors.
Participant Demographics
The study included 61,433 women aged 40-76 from Uppsala and Västmanland Counties in Sweden.
Statistical Information
P-Value
0.04
Confidence Interval
0.47–0.96
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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