Lack of DMBT1 expression in oesophageal, gastric and colon cancers
1999
Lack of DMBT1 expression in oesophageal, gastric and colon cancers
Sample size: 107
publication
Evidence: moderate
Author Information
Author(s): Mori M, Shiraishi T, Tanaka S, Yamagata M, Mafune K, Tanaka Y, Ueo H, Barnard G F, Sugimachi K
Primary Institution: Department of Surgery, Medical Institute of Bioregulation, Kyushu University, Beppu, Japan
Hypothesis
DMBT1 may act as a tumour-suppressor gene in gastrointestinal cancers.
Conclusion
The study found reduced DMBT1 mRNA expression in a significant number of cancer cases, suggesting its role as a tumour-suppressor gene.
Supporting Evidence
- 53.5% of oesophageal cancer cases showed reduced DMBT1 mRNA expression.
- 12.5% of gastric cancer cases showed reduced DMBT1 mRNA expression.
- 16.7% of colorectal cancer cases showed reduced DMBT1 mRNA expression.
- 11.6% of primary oesophageal tumours had homozygous deletions of DMBT1.
Takeaway
The DMBT1 gene, which helps prevent cancer, is not working properly in many patients with oesophageal, gastric, and colon cancers.
Methodology
The study used RT-PCR to analyze mRNA expression and duplex PCR for detecting homozygous deletions in cancer tissues.
Digital Object Identifier (DOI)
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