Structure and Reactivity of Myochrysine Solutions
Author Information
Author(s): R.C. Elder, William B. Jones, Zheng Zhao, John G. Dorsey, Katherine Tepperman
Primary Institution: Biomedical Chemistry Research Center, University of Cincinnati
Hypothesis
Is the structure of Myochrysine relevant to the dilute solutions of drugs administered and the lower concentrations of gold found in patients' bodies?
Conclusion
Myochrysine solutions remain oligomeric at concentrations found in patient blood and urine.
Supporting Evidence
- EXAFS studies confirm that the polymeric structure persists from molar concentrations down to millimolar concentrations.
- CZE is able to separate and detect Myochrysine at millimolar levels.
- At micromolar levels, Myochrysine solutions exhibit identical CZE behavior to that measured at millimolar levels.
Takeaway
Myochrysine, a gold-based drug, keeps its structure even when diluted to levels found in patients, which is important for understanding how it works in the body.
Methodology
The study used extended X-ray absorption spectroscopy (EXAFS) and capillary zone electrophoresis (CZE) to analyze Myochrysine at various concentrations.
Limitations
The study was performed in the absence of additional endogenous thiols found in the human body, which may affect the drug's behavior in vivo.
Statistical Information
P-Value
0.0006 M^-1
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