Cyclin D1 and Lung Cancer Outcomes
Author Information
Author(s): Mishina T, Dosaka-Akita H, Kinoshita I, Hommura F, Morikawa T, Katoh H, Kawakami Y
Primary Institution: Hokkaido University School of Medicine
Hypothesis
How does cyclin D1 expression relate to p53 expression, cell proliferation, and clinical outcomes in non-small-cell lung cancers?
Conclusion
Cyclin D1 expression is associated with altered p53 expression and better survival outcomes in patients with non-small-cell lung cancers.
Supporting Evidence
- Cyclin D1 was expressed in 11.7% of the NSCLCs studied.
- Cyclin D1 expression significantly correlated with altered p53 protein expression (P = 0.04).
- Patients with cyclin D1+ tumors had a 5-year survival rate of 89%, compared to 64% for cyclin D1- tumors.
Takeaway
This study found that a protein called cyclin D1 is linked to better survival in lung cancer patients, especially when another protein, p53, is also affected.
Methodology
Cyclin D1 expression was studied using immunohistochemistry in 111 resected NSCLCs, and the cyclin D1 gene was analyzed in 29 NSCLCs.
Participant Demographics
77 patients with potentially curatively resected NSCLCs between 1990 and 1995.
Statistical Information
P-Value
0.045
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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