3-(5-Chloronaphthalene-1-sulfonamido)-2-(2-hydroxyethyl)-4,5,6,7-tetrahydro-2H-pyrazolo[4,3-c]pyridin-5-ium chloride
2011
Crystal Structure of a New Compound with Potential Anti-Cancer Properties
publication
Evidence: moderate
Author Information
Author(s): Bai Xiao-Guang, Liu Hong-Tao, Wang Yu-Cheng, Wang Ju-Xian
Primary Institution: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College
Hypothesis
The study aims to synthesize and characterize a new compound that may act as a potential anti-cancer kinase inhibitor.
Conclusion
The synthesized compound exhibits a stable crystal structure characterized by specific hydrogen bonding interactions.
Supporting Evidence
- The compound was synthesized with a one-step yield of 98%.
- The crystal structure was stabilized by hydrogen bonds and π-π stacking interactions.
- The dihedral angle between the pyrazole and naphthalene rings was measured at 75.19°.
Takeaway
The researchers made a new chemical compound that might help fight cancer, and they figured out what it looks like at a tiny level.
Methodology
The compound was synthesized through a series of chemical reactions and characterized using X-ray diffraction.
Digital Object Identifier (DOI)
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