Somatostatin for Bleeding Oesophagitis or Ulceration After Sclerotherapy for Oesophageal Varices
Author Information
Author(s): S.A. Jenkins, R. Shields, N. Jaser, S. Ellenbogen, C. Makin, E. Naylor, M. Newstead, J.N. Baxter
Hypothesis
Somatostatin may be effective in controlling hemorrhage after sclerotherapy for esophageal varices.
Conclusion
Somatostatin is effective in controlling hemorrhage and preventing rebleeding in patients with bleeding from oesophagitis or ulcers following sclerotherapy.
Supporting Evidence
- Somatostatin was effective in controlling hemorrhage in all patients with bleeding from oesophagitis.
- Somatostatin controlled bleeding in 12 of the 14 patients with ulcers.
- Two patients required additional bolus injections of somatostatin to control persistent bleeding.
Takeaway
This study shows that somatostatin can help stop bleeding in patients who have had problems after treatment for varices in the esophagus.
Methodology
Twenty-two patients were treated with intravenous somatostatin after experiencing severe hemorrhage from oesophagitis or ulcers following sclerotherapy.
Limitations
Some patients required additional treatment despite somatostatin, indicating variability in response.
Participant Demographics
Patients included 8 with oesophagitis and 14 with ulcers.
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