Measuring Alkaline Phosphatase in Hodgkin's Disease
Author Information
Author(s): A. Thyss, M. Schneider, C. Caldani, M. Viot, J. Bourry
Primary Institution: Centre Antoine-Lacassagne
Hypothesis
Does the alpha 1 fraction of alkaline phosphatase provide more valuable information in Hodgkin's disease than total alkaline phosphatases?
Conclusion
The alpha 1 fraction of alkaline phosphatase is significantly correlated with disease stage and symptoms in Hodgkin's disease.
Supporting Evidence
- The presence of the alpha 1 fraction was found in 27% of patients at the first perceptible disease stage.
- The alpha 1 fraction was detected in 90% of patients at relapse.
- None of the patients in complete remission showed the alpha 1 fraction.
Takeaway
Doctors can learn more about how far Hodgkin's disease has spread by checking a specific part of a blood test called the alpha 1 fraction of alkaline phosphatase.
Methodology
Electrophoretic isoenzyme separation was used to measure the alpha 1 fraction of alkaline phosphatase in patients with Hodgkin's disease.
Limitations
The study may not account for all possible liver pathologies and relies on biopsy results for definitive diagnosis.
Participant Demographics
83 patients with Hodgkin's disease (57 men, 26 women; mean age 38 for men, 35 for women).
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Want to read the original?
Access the complete publication on the publisher's website