Significance of CaMBr8 Antigen in Breast Cancer
Author Information
Author(s): P. Fachenrs, F. Perrone, S. Menard, S. Andreola, P. Bazzini, R. Bufalino, S. Canevanr, N. Cascinelli, E. Colzani, G. Di Fronzo, M.I. Colnaghi
Primary Institution: Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy
Hypothesis
Does the expression of the CaMBr8 antigen have prognostic value in breast cancer patients?
Conclusion
CaMBr8 expression does not significantly influence survival in breast cancer patients, but it may identify a subgroup that does not respond to hormone therapy.
Supporting Evidence
- CaMBr8 expression was associated with negative prognostic factors like premenopausal status and lymph node invasion.
- Patients with lobular or mixed breast carcinoma showed a worse prognosis associated with CaMBr8 expression.
- 70% of the tumors in the second series expressed hormone receptors, which were inversely related to CaMBr8 expression.
Takeaway
This study looked at a protein called CaMBr8 in breast cancer and found that it doesn't help predict how long patients will live, but it might show who won't do well with hormone treatments.
Methodology
The study analyzed two series of breast cancer patients: a retrospective series of 862 patients and a prospective series of 116 patients, evaluating CaMBr8 expression and its association with various prognostic factors and hormone-receptor levels.
Limitations
The study's findings may not apply to all breast cancer types, as significant relationships were only observed in lobular or mixed breast carcinoma.
Participant Demographics
The study included 862 patients from 1968 to 1971 and 116 patients from 1985, with a median follow-up of 19 years.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
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