Genetic Factors in Kidney Disease in Children
Author Information
Author(s): Elshamaa Manal F, Sabry Samar M, Bazaraa Hafez M, Koura Hala M, Elghoroury Eman A, Kantoush Nagwa A, Thabet Eman H, Abd-El Haleem Dalia A
Primary Institution: National Research Centre, Cairo, Egypt
Hypothesis
The study investigates the association between polymorphisms of the ACE and AT1R genes and the occurrence of renal disease in children.
Conclusion
The ACE DD and AT1R A/C genotypes are associated with hypertension and renal damage in children with end-stage renal disease.
Supporting Evidence
- ACE DD genotype was significantly more frequent in MHD patients compared to controls.
- 89% of DD genotype patients were hypertensive compared to 61% of non-DD genotype patients.
- The C allele of AT1R was independently associated with hypertension.
- ACE activity was higher in patients with the DD genotype.
- Patients with the C allele had higher serum ACE activity.
Takeaway
This study looked at how certain genes might make kids with kidney disease more likely to have high blood pressure and other problems.
Methodology
The study included 76 pediatric patients with advanced CKD and 70 healthy controls, measuring serum ACE activity and genotyping for ACE and AT1R polymorphisms.
Potential Biases
Potential bias due to the small sample size and selection from a single center.
Limitations
The study had a small sample size and was conducted at a single center, which may limit the generalizability of the findings.
Participant Demographics
Pediatric patients with advanced chronic kidney disease, ages not specified.
Statistical Information
P-Value
0.0001
Confidence Interval
95% CI (0.07-0.24)
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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