Genomic Diversity and Evolution of Streptococcus suis Serotype 2
Author Information
Author(s): Wu Zuowei, Li Ming, Wang Changjun, Li Jing, Lu Na, Zhang Ruifen, Jiang Yongqiang, Yang Ruifu, Liu Cuihua, Liao Hui, Gao George F, Tang Jiaqi, Zhu Baoli
Primary Institution: CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China
Hypothesis
The genome of Streptococcus suis serotype 2 (SS2) would be highly polymorphic among different strains.
Conclusion
The study revealed significant genomic polymorphisms in SS2 populations, indicating that some virulent strains acquired genes contributing to streptococcal toxic shock syndrome (STSS).
Supporting Evidence
- The 89K pathogenicity island was found to be partially included in some other virulent and avirulent strains.
- A model of microevolution for SS2 strains was proposed based on genomic analysis.
- Polymorphisms in genes encoding candidate virulence factors were identified.
Takeaway
Scientists studied different strains of a bacteria called Streptococcus suis to see how they change and become harmful. They found that some strains have special genes that make them dangerous.
Methodology
Comparative genomic analysis using NimbleGen tiling arrays on 18 selected SS2 strains based on virulence and geographic origin.
Limitations
The CGS method cannot identify recently gained genes due to technical limitations.
Digital Object Identifier (DOI)
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