Anti-gonadotrophin releasing hormone antibodies inhibit the growth of MCF7 human breast cancer xenografts
1999
Anti-GnRH Antibodies and Breast Cancer Growth
publication
Evidence: moderate
Author Information
Author(s): Jacobs E, Watson S A, Michaeli D, Ellis I O, Robertson J F R
Primary Institution: Professorial Unit of Surgery, City Hospital, Nottingham, UK
Hypothesis
Can anti-gonadotrophin releasing hormone antibodies inhibit the growth of breast cancer xenografts?
Conclusion
Anti-GnRH antibodies significantly inhibited the growth of breast cancer xenografts in mice.
Supporting Evidence
- Xenografts did not require oestrogen supplementation for growth.
- Anti-GnRH antibodies significantly inhibited xenograft growth compared to controls.
- The inhibition of tumour growth was similar to that produced by tamoxifen.
- Ovarian/uterine weights were reduced by 61% in treated animals compared to controls.
- Serum levels of oestrogen and luteinizing hormone were significantly reduced by treatment.
Takeaway
This study found that a special treatment can slow down the growth of breast cancer in mice by lowering certain hormone levels.
Methodology
The study used MCF7 breast cancer xenografts in nude mice treated with anti-GnRH antibodies.
Participant Demographics
Intact female nude mice were used in the study.
Statistical Information
P-Value
p < 0.001
Statistical Significance
p < 0.001
Digital Object Identifier (DOI)
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