Interferon Genes and Type 1 Diabetes
Author Information
Author(s): Morris Gerard AJ, Lowe Christopher E, Cooper Jason D, Payne Felicity, Vella Adrian, Godfrey Lisa, Hulme John S, Walker Neil M, Healy Barry C, Lam Alex C, Lyons Paul A, Todd John A
Primary Institution: Juvenile Diabetes Research Foundation/Wellcome Trust Diabetes and Inflammation Laboratory, Cambridge Institute for Medical Research, University of Cambridge
Hypothesis
Is there an association between type 1 diabetes and polymorphisms in interferon genes?
Conclusion
The study found no significant association between type 1 diabetes and the interferon genes tested.
Supporting Evidence
- 238 variants were identified, including 98 novel SNPs.
- A total of 45 tag SNPs were selected and genotyped in 472 multiplex families.
- No statistical evidence of a major association between T1D and the interferon genes was found.
Takeaway
The researchers looked at genes related to interferons to see if they are linked to type 1 diabetes, but they didn't find any strong connections.
Methodology
The study used a linkage disequilibrium mapping approach and genotyped tag SNPs in multiplex families.
Limitations
The study may not have detected smaller effects or variants in weaker linkage disequilibrium.
Participant Demographics
The study involved multiplex families with type 1 diabetes.
Digital Object Identifier (DOI)
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