Rosiglitazone's Effect on Blood Pressure in Type 2 Diabetes
Author Information
Author(s): Komajda Michel, Curtis Paula, Hanefeld Markolf, Beck-Nielsen Henning, Pocock Stuart J, Zambanini Andrew, Jones Nigel P, Gomis Ramon, Home Philip D
Primary Institution: Université Pierre et Marie Curie Paris 6; Assistance Publique Hôpitaux de Paris, Hôpital Pitié-Salpêtrière, Paris, France
Hypothesis
Does adding rosiglitazone to metformin or sulfonylureas lower blood pressure more effectively than using metformin and sulfonylureas together in people with type 2 diabetes?
Conclusion
Adding rosiglitazone to metformin or a sulfonylurea significantly reduces ambulatory blood pressure compared to the combination of metformin and sulfonylureas.
Supporting Evidence
- Rosiglitazone significantly reduced 24-hour ambulatory systolic blood pressure compared to metformin.
- The reduction in diastolic blood pressure was also significant with rosiglitazone compared to sulfonylureas.
- No compensatory increase in heart rate was observed with rosiglitazone treatment.
Takeaway
This study found that taking rosiglitazone with other diabetes medications helps lower blood pressure better than just using the other two medications together.
Methodology
Participants were randomized to receive either rosiglitazone or a comparator medication while continuing their existing diabetes treatment, with blood pressure monitored over 12 months.
Potential Biases
Potential bias due to the open-label design and the possibility of participant or physician preference affecting treatment adherence.
Limitations
The study was open-label, which could introduce bias, and background antihypertensive therapies could be modified during the study.
Participant Demographics
Participants were aged 40-75 years, predominantly Europid, with a mean age of around 57 years and a high prevalence of hypertension.
Statistical Information
P-Value
0.015
Confidence Interval
95% CI 0.5–4.9
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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