Humic Acid from Vermicompost Helps Bone Health and Protects Kidneys in Periodontitis
Author Information
Author(s): Lima Karen Rodrigues, Tavares Hugo Giordano, Pereira Ramona Ramalho de Souza, Carvalho Jaqueline do Carmo Lima, Botelho Roberta de Oliveira, Reis Spuri Aline Chaves, Dobbss Leonardo Barros, Machado Alan Rodrigues Teixeira, Orlando Débora Ribeiro, Remédio Rafael Neodini, de Paiva Saul Martins, de Moura Rodrigo Ferreira, Dias-Peixoto Marco Fabrício, Pereira Luciano José, Andrade Eric Francelino
Primary Institution: Universidade Federal de Lavras (UFLA)
Hypothesis
Does humic acid derived from vermicompost have protective effects against alveolar bone degradation and renal injury in periodontitis?
Conclusion
Humic acid treatment improves alveolar bone integrity and reduces renal lesions caused by periodontitis.
Supporting Evidence
- HA-treated animals showed reduced epithelial attachment loss and alveolar bone loss.
- Renal lesions observed in PD animals were mitigated at 40 and 80 mg/kg HA doses.
- HA treatment improved bone quality parameters, such as reduced pore number and diameter.
Takeaway
This study found that a natural substance called humic acid can help keep your teeth and bones healthy and protect your kidneys when you have gum disease.
Methodology
Fifty-four Wistar rats were divided into six groups and treated with different doses of humic acid for 28 days, with periodontal disease induced on day 14.
Limitations
The study did not assess local inflammatory markers or the effects on female animals.
Participant Demographics
Healthy male Wistar rats, eight weeks old.
Statistical Information
P-Value
p<0.05
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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