Remote Ischemic Preconditioning and Kidney Protection in Surgery
Author Information
Author(s): Tao Ziying, Zhang Yang, Kong Erliang, Wei Haili, Li Mingyue, Sun Shuhui, Liu Liwei, Yin Daqing, Feng Xudong
Primary Institution: The 988th Hospital of Joint Logistic Support Force of Chinese People’s Liberation Army, Zhengzhou, China
Hypothesis
This study aimed to investigate the renoprotective effect of remote ischemic preconditioning (RIPC) in patients undergoing extremity surgery with repeated tourniquet application.
Conclusion
RIPC effectively mitigated acute kidney injury caused by repeated tourniquet application, offering a robust method for perioperative renal protection in patients undergoing extremity surgery.
Supporting Evidence
- The RIPC group showed a significant decrease in BUN and SCr at 48 hours postoperatively.
- Levels of Cys-C, [TIMP-2] × [IGFBP-7], KIM-1, IL-18, and NGAL were significantly reduced in the RIPC group.
- MDA levels were significantly lower and SOD levels were significantly higher in the RIPC group compared to the control group.
Takeaway
Using a special technique called remote ischemic preconditioning before surgery can help protect the kidneys from damage caused by tourniquets.
Methodology
This was a prospective, randomized controlled clinical trial with 64 patients divided into RIPC and control groups, measuring various renal and oxidative stress biomarkers.
Potential Biases
The potential impact of anesthetic drugs on outcomes was not considered.
Limitations
The study was conducted as a single-center study with a limited sample size, which may affect the generalizability of the results.
Participant Demographics
60 patients, comprising 48 males and 12 females, aged 20-50 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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