HPV Detection in Amniotic Fluid

Sample size: 146 publication Evidence: moderate

Author Information

Author(s): Ruffin Mack T IV, Bailey Joanne M, Roulston Diane, Lee Daisy R, Tucker Ruth Ann, Swan David C, Unger Elizabeth R

Primary Institution: University of Michigan

Can HPV be detected in amniotic fluid from women with intact membranes?

No HPV was detected in the amniotic fluid samples from the study participants.

All samples were β-globin positive.
No HPV was detected in any of the amniotic fluid or pellet cell samples.
The study had 80–85% power to detect HPV prevalence.
Other studies have reported similar findings regarding HPV detection in amniotic fluid.

The study looked for a virus called HPV in the fluid around babies before they are born, but they didn't find any.

The study used residual amniotic fluid and cell pellets from amniocentesis and employed PCR methods to detect HPV.

The study could not determine the HPV status of the participants or their risk for having HPV.

The participants were 78% Caucasian, 5% African American, 14% Asian, and 2% Hispanic, with an average age of 35.2 years.

80–85% power to detect prevalence of HPV from 1% to 10%.

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