Generating HPV Specific T Helper Cells for Cancer Treatment
Author Information
Author(s): Kirsten BJ Scholten, Annelies W Turksma, Janneke J Ruizendaal, Muriel van den Hende, Sjoerd H van der Burg, Mirjam HM Heemskerk, Chris JLM Meijer, Erik Hooijberg
Primary Institution: VU University Medical Center
Hypothesis
Can TCR gene transfer effectively generate HPV specific CD4+ T helper cells for treating HPV induced malignancies?
Conclusion
TCR transfer is a feasible strategy to create HPV16 specific CD4+ T helper cells for treating cervical cancer and other HPV16 induced malignancies.
Supporting Evidence
- HPV16 specific TCRs were successfully introduced into CD4+ T cells.
- Functional analysis showed recognition of HPV16 epitopes by TCR transgenic CD4+ T cells.
- Both Th1 and Th2 cytokines were produced by TCR transgenic CD4+ T cells upon stimulation.
Takeaway
Scientists are trying to make special immune cells that can fight HPV-related cancers by using a method called TCR gene transfer.
Methodology
HPV specific CD4+ T cells were generated using TCR gene transfer and analyzed for functionality through various assays.
Limitations
The study does not address the long-term effectiveness or safety of TCR gene transfer in patients.
Digital Object Identifier (DOI)
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