Chromogranin A as a Prognostic Factor in Small Cell Lung Cancer
Author Information
Author(s): Drivsholm L, Paloheimo L I, Østerlind K
Primary Institution: Rigshospitalet, Copenhagen, Denmark
Hypothesis
Chromogranin A can serve as a clinical tumor marker and prognostic factor in small cell lung cancer.
Conclusion
Chromogranin A levels are significantly related to the stage of small cell lung cancer and can help predict patient prognosis.
Supporting Evidence
- 37% of patients had elevated pretreatment Chromogranin A values.
- Chromogranin A values were significantly related to the stage of disease.
- A prognostic index was established based on four pretreatment features.
Takeaway
Chromogranin A is a protein that can help doctors understand how serious small cell lung cancer is and how long patients might live.
Methodology
A two-site enzyme-linked immunosorbent assay was used to measure Chromogranin A in plasma from newly diagnosed small cell lung cancer patients.
Participant Demographics
Newly diagnosed patients with small cell lung cancer.
Statistical Information
Confidence Interval
95% CI: 311–537, 261–459, 105–243
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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