Ciprofol and Sufentanil for Laryngeal Mask Airway Insertion in Young and Older Patients
Author Information
Author(s): Zhou Xuelei, Zhao Li, Mao Wei, Chen Linlin, Liu Xianchun
Primary Institution: The Second Clinical Medical College, North Sichuan Medical College, Nanchong Central Hospital, Nanchong, China
Hypothesis
What is the median effective dose (ED50) of ciprofol required to suppress the laryngeal mask airway insertion response in both young and older adult patients?
Conclusion
The study found significant differences in the ED50 of ciprofol for suppressing the LMA insertion response between young and older adult patients.
Supporting Evidence
- The ED50 of ciprofol for young adults was 0.38 mg·kg−1.
- The ED50 of ciprofol for older adults was 0.29 mg·kg−1.
- The confidence intervals for ED50 did not overlap between the two age groups.
- Statistically significant differences were found in ASA grades and gender between the groups.
Takeaway
This study shows that younger patients need more ciprofol to handle the insertion of a breathing tube than older patients.
Methodology
46 patients were given ciprofol and sufentanil before LMA insertion, and the ED50 was calculated using logistic regression and bootstrap resampling.
Potential Biases
The study's design may have biases due to the differences in health profiles of the age groups.
Limitations
The study had a limited sample size and differences in ASA classifications between age groups, which may affect the results.
Participant Demographics
Participants were divided into two age groups: young adults (18-44 years) and older adults (60-79 years).
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI, 0.35–0.41 for young adults; 95% CI, 0.26–0.32 for older adults
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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