Brain-derived Neurotrophic Factor Regulates Energy Expenditure Through the Central Nervous System in Obese Diabetic Mice
2001
BDNF Regulates Energy Use in Obese Diabetic Mice
Sample size: 9
publication
Evidence: moderate
Author Information
Author(s): TAKESHI NONOMURA, ATSUSHI TSUCHIDA, MICHIKO ONO-KISHINO, TSUTOMU NAKAGAWA, MUTSUO TAIJI, HIROSHI NOGUCHI
Primary Institution: Sumitomo Pharmaceuticals Co. Ltd.
Hypothesis
BDNF regulates glucose metabolism by acting through the central nervous system.
Conclusion
The study shows that BDNF administration lowers blood glucose and increases insulin content in obese diabetic mice.
Supporting Evidence
- BDNF treatment lowered blood glucose levels in db/db mice.
- Intracerebroventricular BDNF administration increased pancreatic insulin content.
- BDNF enhanced norepinephrine turnover in brown adipose tissue.
- BDNF administration improved body temperature regulation in food-deprived mice.
Takeaway
This study found that a brain protein called BDNF helps mice with diabetes use energy better and lowers their blood sugar.
Methodology
Intracerebroventricular administration of BDNF was performed on db/db mice to assess its effects on glucose metabolism and energy expenditure.
Participant Demographics
Male C57BL/KsJ-db/db mice, aged 10-12 weeks.
Statistical Information
P-Value
0.002
Statistical Significance
p<0.05
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