Inhibition of breast cancer growth in vivo by antiangiogenesis gene therapy with adenovirus-mediated antisense-VEGF
2001
Gene Therapy to Stop Breast Cancer Growth
publication
Evidence: moderate
Author Information
Author(s): Im S-A, Kim J-S, Gomez-Manzano C, Fueyo J, Liu T-J, Cho M-S, Seong C-M, Lee S N, Hong Y-K, Yung W K A
Primary Institution: Ewha Medical Research Center, Ewha Womans University
Hypothesis
Can adenovirus-mediated antisense VEGF gene therapy inhibit breast cancer growth?
Conclusion
The study found that the adenoviral vector significantly inhibited the growth of breast tumors in mice.
Supporting Evidence
- The adenoviral vector reduced VEGF protein levels in breast cancer cells.
- Injection of the vector into tumors in mice inhibited tumor growth.
- The treatment reduced the density of microvessels in the tumors.
Takeaway
Scientists used a special virus to help stop breast cancer from growing in mice, and it worked really well.
Methodology
The study used an adenoviral vector to deliver antisense VEGF cDNA to breast cancer cells and tested its effects in mice.
Participant Demographics
Nude mice were used for the experiments.
Digital Object Identifier (DOI)
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