Polymorphism of the Tryptophan Hydroxylase 2 (TPH2) Gene Is Associated with Chimpanzee Neuroticism
2011

Chimpanzee Neuroticism and the TPH2 Gene

Sample size: 57 publication Evidence: moderate

Author Information

Author(s): Hong Kyung-Won, Weiss Alexander, Morimura Naruki, Udono Toshifumi, Hayasaka Ikuo, Humle Tatyana, Murayama Yuichi, Ito Shin'ichi, Inoue-Murayama Miho

Primary Institution: The United Graduate School of Agricultural Science, Gifu University, Gifu, Japan

Hypothesis

Is the Q468R polymorphism in the TPH2 gene associated with neuroticism in chimpanzees?

Conclusion

The Q468R polymorphism in the TPH2 gene is significantly associated with higher levels of neuroticism in chimpanzees.

Supporting Evidence

  • The Q468R allele was significantly related to higher neuroticism scores.
  • Findings suggest a genetic basis for personality traits in chimpanzees.
  • The study is the first to link a genotype to a personality trait in great apes.
  • Similar associations have been found in humans and other species.

Takeaway

This study found that a specific gene in chimpanzees is linked to their personality, especially how anxious or nervous they can be.

Methodology

The study involved analyzing the TPH2 gene polymorphism and its association with neuroticism in 57 chimpanzees using linear regression models.

Potential Biases

Potential bias due to the small sample size and the non-random selection of chimpanzees.

Limitations

The small sample size limits the generalizability of the findings, and there is a lack of background information on the chimpanzees.

Participant Demographics

The sample included 57 chimpanzees, with 21 wild-born orphans from Guinea and the rest from various facilities in Japan.

Statistical Information

P-Value

0.005

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0022144

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