Lewis Antigen Expression in Bladder and Colon Cancer Patients
Author Information
Author(s): N.C. Langkilde, H. Wolf, P. Meldgard, T.F. Orntoft
Primary Institution: The Danish Cancer Society
Hypothesis
Is there an increased risk of cancer development among Lewis negative patients?
Conclusion
The study found that Lewis negative individuals have a higher frequency of invasive cancer and unfavorable disease parameters.
Supporting Evidence
- An increased frequency of Lewis negative individuals was found among colon cancer patients.
- The Lewis negative phenotype was associated with high grade of atypia in bladder cancer patients.
- Four out of eight Lewis negative cancer patients had Lewis transferase activity in saliva.
Takeaway
Some people with bladder and colon cancer lose a specific marker in their blood, which might mean their cancer is more serious.
Methodology
Blood and saliva samples were collected from cancer patients and analyzed for Lewis phenotypes and disease parameters.
Potential Biases
Potential bias in patient selection and the interpretation of phenotypes.
Limitations
The study did not include a diverse population and focused only on specific cancer types.
Participant Demographics
82 bladder cancer patients, 21 colon cancer patients, and 45 patients with benign urological diseases.
Statistical Information
P-Value
p<0.004
Statistical Significance
p<0.004
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