Haemophilus influenzae type B vaccination and risk of childhood leukaemia in a vaccine trial in Finland
2000
Vaccination Against Childhood Leukaemia
Sample size: 114000
publication
Evidence: moderate
Author Information
Author(s): Auvinen A, Hakulinen T, Groves F
Primary Institution: STUK – Radiation and Nuclear Safety Authority
Hypothesis
Does early vaccination against Haemophilus influenzae type b reduce the risk of childhood leukaemia?
Conclusion
Early immunization against Hib may reduce the incidence of childhood leukaemia, but further studies are needed to confirm this.
Supporting Evidence
- Among 114,000 subjects, 77 cases of childhood leukaemia were detected.
- The incidence of childhood leukaemia was lower in the early vaccination arm compared to the late vaccination arm.
Takeaway
Getting vaccinated early might help lower the chances of getting leukaemia when you're a child.
Methodology
The study compared the incidence of childhood leukaemia between two vaccination schedules in a large trial.
Limitations
The difference in leukaemia incidence did not reach statistical significance, indicating uncertainty in the results.
Statistical Information
Confidence Interval
0.46–1.13
Digital Object Identifier (DOI)
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