S100A7/psoriasin expression in the human lung and its relation to COPD and S. aureus
Author Information
Author(s): Andresen Ellen, Lange Christoph, Strodthoff Daniela, Goldmann Torsten, Fischer Nicole, Sahly Hany, Branscheid Detlev, Heine Holger
Primary Institution: Research Center Borstel, Leibniz-Center for Medicine and Biosciences, Germany
Hypothesis
S100A7/psoriasin is involved in the airway mucosal immunity and differently regulated and expressed in the lung during progression of COPD.
Conclusion
S100A7/psoriasin gene expression is unchanged in the airways during COPD, but is upregulated upon detection of S. aureus.
Supporting Evidence
- S100A7/psoriasin is constitutively expressed in perinuclear granules of human bronchial epithelial cells and alveolar macrophages.
- S100A7/psoriasin mRNA expression was not modulated by typical activators of the innate immune response.
- An association of S100A7/psoriasin mRNA expression with bacterial detection in the tracheobronchial system was found.
Takeaway
This study looked at a protein called S100A7/psoriasin in the lungs of people with COPD and found that it doesn't change much with the disease, but it does increase when certain bacteria are present.
Methodology
Gene expression was assessed in bronchial biopsies and bronchoalveolar lavage fluid cells of healthy controls and COPD patients using confocal microscopy and immunohistochemistry.
Limitations
The study did not find significant differences in S100A7/psoriasin expression levels between COPD patients and healthy individuals.
Participant Demographics
10 healthy controls and 34 COPD patients across stages 1-4.
Statistical Information
P-Value
0.0304
Statistical Significance
p = 0.0005
Digital Object Identifier (DOI)
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