Cold Agglutinin and Cryoglobulin in Severe Anemia After COVID-19
Author Information
Author(s): Muacevic Alexander, Adler John R, Kaneko Masahiko, Masuda Yuya, Ishikawa Kenichi, Shikata Hisaharu
Primary Institution: Uwajima City Hospital
Hypothesis
Can cold agglutinin and cryoglobulin coexist in a patient with severe anemia following COVID-19 infection?
Conclusion
The patient's anemia improved with folic acid supplementation, despite ongoing positivity for cryoglobulinemia without clinical symptoms.
Supporting Evidence
- The patient had a history of COVID-19 infection and developed severe anemia.
- Direct antiglobulin testing showed C3d positivity and IgG negativity.
- Anemia improved with folic acid supplementation alone.
Takeaway
A 73-year-old man had severe anemia after COVID-19, but his condition got better with folic acid, even though he still tested positive for certain blood proteins.
Methodology
Case report detailing clinical findings, laboratory tests, and treatment outcomes.
Limitations
Only one case is reported, limiting generalizability.
Participant Demographics
73-year-old Japanese male.
Digital Object Identifier (DOI)
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