Comparing SMS 201-995 and Oesophageal Tamponade for Variceal Bleeding
Author Information
Author(s): Ruth F. McKee, O.J. Garden, J.R. Anderson, D.C. Carter
Primary Institution: University Department of Surgery, Royal Infirmary, Glasgow, United Kingdom
Hypothesis
Is SMS 201-995 as effective as oesophageal tamponade in controlling acute variceal hemorrhage?
Conclusion
SMS 201-995 infusion has comparable efficacy to oesophageal tamponade in controlling variceal bleeding.
Supporting Evidence
- Oesophageal tamponade controlled 19 of 20 bleeds over the first four hours.
- SMS 201-995 infusion controlled 18 of 20 bleeds over the first four hours.
- Complications in the oesophageal tamponade group included discomfort and chest infections.
- All patients in the SMS 201-995 group survived their admission.
Takeaway
Doctors tested two treatments for bleeding in the esophagus and found that both worked well, but one was easier for patients.
Methodology
Patients with active variceal bleeding were randomly assigned to receive either SMS 201-995 infusion or oesophageal tamponade.
Potential Biases
Randomization may not have fully accounted for differences in liver function between groups.
Limitations
The study had a small sample size and may not represent all patients with variceal bleeding.
Participant Demographics
The study included 40 patients with active variceal bleeding, with a sex ratio of 34 males to 6 females.
Statistical Information
P-Value
0.047
Statistical Significance
p<0.05
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