Synthesis and Characterization of Coordinatively Unsaturated Copper (II) Complexes of 1,3-Bis(2'-Pyridyl)-1,2-Diaza-2-Butene and Their Antityrosinase Activity
1998
Copper Complexes and Their Effects on Tyrosinase Activity
publication
Evidence: moderate
Author Information
Author(s): Ratnamala Bendre, Anupa Murugkar, Subhash Padhye, Pallavi Kulkarni, Meena Karve
Primary Institution: University of Pune
Hypothesis
The nature and extent of inhibition of tyrosinase can be modulated by the type of ancillary anions in copper complexes.
Conclusion
The synthesized copper complexes exhibit varying inhibitory activities against mushroom tyrosinase, influenced by the type of ancillary anions.
Supporting Evidence
- The copper complexes showed inhibitory activities against mushroom tyrosinase.
- The extent of inhibition varied from 10% to 25% depending on the ancillary ligands.
- Complexation of copper ions influenced the nature of inhibition from non-competitive to competitive.
Takeaway
The study shows that certain copper compounds can stop a specific enzyme from working, and changing the ingredients can change how well they work.
Methodology
Copper complexes were synthesized and their inhibitory effects on mushroom tyrosinase were measured spectrophotometrically.
Want to read the original?
Access the complete publication on the publisher's website