Improving Patient Recruitment for Clinical Trials
Author Information
Author(s): Dugas Martin, Lange Matthias, Berdel Wolfgang E, Müller-Tidow Carsten
Primary Institution: University of Münster
Hypothesis
Can routine hospital data be used to enhance patient recruitment for clinical trials?
Conclusion
Routine HIS data can be used to support patient recruitment for clinical trials by means of an automated notification workflow.
Supporting Evidence
- 41 patients were identified by the system during a 50-day test period.
- 13 new trial patients were included, while 7 were already part of earlier visits.
- No AML trial patient was missed according to paper record reviews.
Takeaway
The study created a system that helps hospitals find patients for clinical trials by using their medical records automatically.
Methodology
A workflow was developed to use routine data from a hospital information system to identify potential trial subjects, with notifications sent to study nurses or physicians for eligibility verification.
Potential Biases
Potential for false positive alerts which could annoy physicians and impact user acceptance.
Limitations
The test period of 50 days may not be long enough for a valid assessment of improved recruitment.
Participant Demographics
Patients with acute myeloid leukemia (AML) in a hospital setting.
Digital Object Identifier (DOI)
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