Healing Effects of Picrorhiza kurroa on Stomach Ulcers in Mice
Author Information
Author(s): Banerjee Debashish, Maity Biswanath, Nag Subrata K, Bandyopadhyay Sandip K, Chattopadhyay Subrata
Primary Institution: Dr. B.C. Roy Post Graduate Institute of Basic Medical Sciences & IPGME&R
Hypothesis
The study aims to evaluate the healing potential of Picrorhiza kurroa rhizomes against indomethacin-induced gastric ulceration in mice.
Conclusion
Picrorhiza kurroa effectively heals indomethacin-induced stomach ulcers in mice by reducing oxidative stress and promoting mucin secretion and growth factor expression.
Supporting Evidence
- PK reduced ulcer indices by 45.1% compared to untreated mice.
- PK increased mucin levels by 42.2% after three days of treatment.
- PK enhanced expressions of COX-1 and COX-2 by 26.9% and 18.5%, respectively.
Takeaway
Picrorhiza kurroa is a plant that helps heal stomach ulcers in mice by making the stomach less damaged and helping it heal faster.
Methodology
Male swiss albino mice were treated with different doses of methanol extract of P. kurroa rhizomes after inducing ulcers with indomethacin.
Limitations
The study was conducted only on mice, and results may not directly translate to humans.
Participant Demographics
Male swiss albino mice, aged 6–8 weeks.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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