CFTR and Wnt/beta-catenin signaling in lung development
2008
CFTR and Wnt/beta-catenin signaling in lung development
publication
Evidence: moderate
Author Information
Author(s): Cohen J Craig, Larson Janet E, Killeen Erin, Love Damon, Takemaru Ken-Ichi
Primary Institution: Stony Brook University, School of Medicine
Hypothesis
The study examines the role of CFTR in modulating Wnt/beta-catenin signaling during lung organogenesis.
Conclusion
CFTR is involved in regulating Wnt/β-Catenin signaling necessary for lung organogenesis.
Supporting Evidence
- CFTR expression levels correlate with PTHrP levels in lung development.
- Inhibition of CFTR leads to increased Wnt signaling activity.
- CFTR overexpression results in a small but significant increase in Wnt signaling.
Takeaway
CFTR helps the lungs grow properly by sensing mechanical stretch and influencing important signals.
Methodology
In utero gene transfer was used to modify CFTR expression in fetal mice and assess its effects on lung development.
Statistical Information
P-Value
p < 0.05; p < 0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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