Human Proteins Interacting with Viruses and Other Pathogens
Author Information
Author(s): Dyer Matthew D, Murali T. M, Sobral Bruno W
Primary Institution: Virginia Polytechnic Institute and State University
Hypothesis
What are the properties of human proteins that interact with pathogens?
Conclusion
The study provides a global view of how pathogens interact with human proteins, revealing common strategies used to manipulate human cellular processes.
Supporting Evidence
- 98.3% of the human-pathogen PPIs are for viral systems.
- 77.9% of the interactions belong to the human-HIV system.
- 221 human proteins interact with at least two pathogen groups.
Takeaway
This study looks at how germs like viruses and bacteria talk to our body's proteins, helping us understand how they make us sick.
Methodology
The study integrated human-pathogen protein-protein interactions from seven public databases.
Potential Biases
The results may be influenced by experimental biases and errors in the human PPI network.
Limitations
Data for bacterial pathogens are scarce, and no single pathogen may target all the proteins analyzed.
Participant Demographics
The study focuses on human proteins interacting with 190 different pathogen strains.
Statistical Information
P-Value
3 × 10−5
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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