Cardioprotective Effects of Hibiscus rosa sinensis in Rats
Author Information
Author(s): Gauthaman Karunakaran, Saleem Mohamed TS, Thanislas Peter T, Prabhu Vinoth V, Krishnamoorthy Karthikeyan K, Devaraj Niranjali S, Somasundaram Jayaprakash S
Primary Institution: K.M. College of Pharmacy, Madurai, India
Hypothesis
The study investigates the cardioprotective effects of Hibiscus rosa sinensis in myocardial ischemic reperfusion injury.
Conclusion
Hibiscus rosa sinensis flowers at a dose of 250 mg/kg enhance antioxidant compounds in rat hearts and protect against myocardial injury.
Supporting Evidence
- The study found significant increases in antioxidant levels in the hearts of rats treated with Hibiscus rosa sinensis.
- The 250 mg/kg dose showed the best results in preventing myocardial injury.
- Histological examinations indicated preserved myocardial structure in treated groups.
Takeaway
This study shows that a flower called Hibiscus rosa sinensis can help protect rat hearts from damage when they are not getting enough blood.
Methodology
Wistar albino rats were treated with different doses of Hibiscus rosa sinensis for 4 weeks, followed by isoproterenol injection to induce myocardial injury.
Limitations
The study was conducted only on rats, and results may not directly translate to humans.
Participant Demographics
Male Wistar albino rats weighing 150–200 grams.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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