Case report: Outflow reconstruction with pre-frozen allograft blood vessels during in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation for locally advanced hepatocellular carcinoma with background of cirrhosis
2024

Surgery for Liver Cancer with Allograft Blood Vessels

Sample size: 2 publication Evidence: moderate

Author Information

Author(s): Chen Jun-Ze, Zhang Cheng, Su Rui-Ling, Jian Yong-Yuan, Huang Kai-Yong, Tan Xue-Lin, Chen Zhao, Liao Yong-Xin, Dong Chun-Qiang, Dong Kun

Primary Institution: Department of Organ Transplantation, the First Affiliated Hospital of Guangxi Medical University, Nanning, China

Hypothesis

Can ex vivo tumor resection and partial liver autotransplantation using pre-frozen allograft blood vessels provide a safe surgical option for cirrhotic patients with hepatocellular carcinoma?

Conclusion

The study suggests that the surgical technique may be a promising and relatively safe option for radical tumor resection in cirrhotic patients.

Supporting Evidence

  • The surgical technique was performed on two cirrhotic patients with hepatocellular carcinoma.
  • Both patients recovered well postoperation without severe complications.
  • Clear margins of the tumor were confirmed by ex vivo resection.
  • No tumor recurrence was observed during 3 months of follow-up.

Takeaway

Doctors used special blood vessels from donors to help two patients with liver cancer have surgery, and both patients did well after the operation.

Methodology

The study involved in vivo partial hepatectomy followed by ex vivo tumor resection and partial liver autotransplantation using pre-frozen allograft blood vessels.

Limitations

The surgical complexities and risk of cancer recurrence in the remaining cirrhotic liver.

Participant Demographics

Two male patients aged 54 and 39, both with a history of hepatitis B and cirrhosis.

Digital Object Identifier (DOI)

10.3389/fonc.2024.1432274

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