Improving Drug Absorption for BCS Class III Drugs through Buccal Delivery
Author Information
Author(s): Sabra Rayan, Kirby Daniel, Chouk Vikram, Malgorzata Kleta, Mohammed Afzal R.
Primary Institution: Aston Pharmacy School, Aston University, Birmingham, UK
Hypothesis
Can innovative formulation strategies enhance the absorption of BCS Class III drugs via buccal delivery?
Conclusion
The review highlights various formulation approaches that can significantly improve the absorption of BCS Class III drugs through buccal delivery.
Supporting Evidence
- Buccal drug delivery can bypass first-pass metabolism, enhancing drug absorption.
- Mucoadhesive polymers can extend the residence time of drugs in the buccal cavity.
- Permeation enhancers can improve drug transport across the buccal mucosa.
- Prodrugs can enhance the solubility and stability of poorly absorbed drugs.
- Adjusting the pH of the microenvironment can improve drug solubility and absorption.
Takeaway
This study looks at ways to help certain medicines get absorbed better in the mouth, making them work faster and better.
Methodology
The review systematically explores various formulation strategies such as permeation enhancers, mucoadhesive polymers, and prodrugs to improve drug absorption.
Limitations
The review does not provide experimental data or specific clinical outcomes related to the discussed strategies.
Digital Object Identifier (DOI)
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