CXCR4 Expression in Renal Cell Carcinoma and Its Link to Disease Progression
Author Information
Author(s): Thomas C. Wehler, Claudine Graf, Stefan Biesterfeld, Walburgis Brenner, Jörg Schadt, Ines Gockel, Martin R. Berger, Joachim W. Thüroff, Peter R. Galle, Markus Moehler, Carl C. Schimanski
Primary Institution: Johannes Gutenberg University of Mainz
Hypothesis
The study aims to evaluate the influence of CXCR4 expression on the progression of human renal cell carcinoma.
Conclusion
Strong CXCR4 expression is significantly associated with advanced dedifferentiated renal cell carcinoma.
Supporting Evidence
- CXCR4 expression was assessed in 113 patients with renal cell carcinoma.
- Strong CXCR4 expression was significantly associated with advanced T-status.
- Strong CXCR4 expression correlated with tumor dedifferentiation.
- Low hemoglobin levels were associated with strong CXCR4 expression.
Takeaway
This study found that when cancer cells have a lot of a certain protein called CXCR4, it often means the cancer is more advanced and harder to treat.
Methodology
CXCR4 expression was assessed by immunohistochemistry in 113 patients, and its intensity was correlated with tumor and patient characteristics.
Participant Demographics
Patients with renal clear cell carcinoma who underwent surgery.
Statistical Information
P-Value
P = .0005
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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