Boosting Cancer Treatment with DT-diaphorase Inducers
Author Information
Author(s): Wang X, Doherty G P, Leith M K, Curphey T J, Begleiter A
Primary Institution: Manitoba Institute of Cell Biology, Manitoba Cancer Treatment and Research Foundation and Departments of Pharmacology and Therapeutics and Internal Medicine, University of Manitoba
Hypothesis
Can the induction of DT-diaphorase enhance the cytotoxic activity of mitomycin C in human tumor cells?
Conclusion
Inducing DT-diaphorase can significantly increase the effectiveness of mitomycin C in certain human tumor cell lines.
Supporting Evidence
- DT-diaphorase can be induced in human tumor cells by dietary compounds.
- Cytotoxicity of mitomycin C increased significantly in four tumor lines.
- The increase in cytotoxicity ranged from 1.4- to threefold.
- Induction of DT-diaphorase did not enhance MMC activity in certain melanoma and gastric cancer cells.
- Toxicity to normal human marrow cells increased by 50% when combined with an inducer.
Takeaway
This study found that some foods can help make cancer treatments work better by boosting a specific enzyme in tumor cells.
Methodology
The study tested the effects of various dietary inducers on DT-diaphorase levels and the subsequent cytotoxicity of mitomycin C in six human tumor cell lines.
Limitations
The study's findings may not apply to all tumor types, as some cell lines did not show increased sensitivity.
Participant Demographics
Human tumor cell lines representing four tumor types were used.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website