Co-stimulation of gastrointestinal tumour cell growth by gastrin, transforming growth factor alpha and insulin like growth factor-I
1991
Gastrin and Growth Factors in Tumor Cell Growth
publication
Evidence: moderate
Author Information
Author(s): L.G. Durrant, S.A. Watson, A. Hall, D.L. Morris
Primary Institution: University of Nottingham
Hypothesis
Do gastrin, TGF-alpha, and IGF-I act independently or additively in controlling gastrointestinal tumor cell growth?
Conclusion
Gastrin, TGF-alpha, and IGF-I can stimulate gastrointestinal tumor cell growth, with some additive effects observed.
Supporting Evidence
- All cell lines expressed both EGF and IGF-I receptors.
- TGF-alpha and IGF-I were both mitogenic for the tested cell lines.
- The optimal dose for growth factor stimulation was found to be 10 ng/ml.
- Combinations of growth factors showed additive effects on cell growth.
- Gastrin enhanced the response of some cell lines to TGF-alpha and IGF-I.
Takeaway
This study found that certain hormones and growth factors help cancer cells grow, and they can work together to make the cells grow even more.
Methodology
The study involved screening various gastric and colorectal tumor cell lines for receptor presence and assessing the mitogenic effects of gastrin, IGF-I, and TGF-alpha.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
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