Hepatitis B Virus Genotypes in Egyptian Pediatric Cancer Patients
Author Information
Author(s): Zekri Abdel-Rahman N, Hafez Mohamed M, Mohamed Nahed I, Hassan Zeinab K, El-Sayed Manal H, Khaled Mohsen M, Mansour Tarek
Primary Institution: National Cancer Institute, Cairo University
Hypothesis
This study aims to determine the HBV genotypes in Egyptian pediatric cancer patients with acute and chronic liver disease.
Conclusion
The study found that HBV infections in pediatric cancer patients are predominantly caused by genotypes D and B, with a notable prevalence of mixed infections.
Supporting Evidence
- HBV genotype D was found in 47.9% of chronic active hepatitis patients.
- Mixed infections accounted for 15.7% of the total infections.
- Genotype B was more prevalent in acute hepatitis cases compared to chronic cases.
Takeaway
Doctors studied kids with cancer in Egypt to see what types of hepatitis B virus they had, and they found that most had two specific types of the virus.
Methodology
HBV genotypes were determined using a type-specific primer based nested-PCR method in 70 pediatric cancer patients.
Potential Biases
Potential bias may arise from the selection of patients attending a single cancer institute.
Limitations
The study had a small sample size and was limited to a specific geographic area.
Participant Demographics
The study included 70 pediatric cancer patients (38 males and 32 females) aged 3 to 18 years.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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