Chemokine Receptors and Their Role in Non-Metastatic Breast Cancer
Author Information
Author(s): Cassier Philippe A, Treilleux Isabelle, Bachelot Thomas, Ray-Coquard Isabelle, Bendriss-Vermare Nathalie, Ménétrier-Caux Christine, Trédan Olivier, Goddard-Léon Sophie, Pin Jean-Jacques, Mignotte Hervé, Bathélémy-Dubois Clarisse, Caux Christophe, Lebecque Serge, Blay Jean-Yves
Primary Institution: Centre Léon Bérard, Lyon, France
Hypothesis
The study investigates the expression of CCR6 and CCR7 chemokine receptors and their ligands in non-metastatic primary breast carcinomas as potential biomarkers for metastatic dissemination.
Conclusion
The study suggests that CCR6 expression on tumor cells and the presence of CCL19-expressing dendritic cells contribute to breast cancer dissemination.
Supporting Evidence
- CCR6 was expressed by tumor cells in 35% of cases.
- CCR7 was expressed by stromal cells in 43% of cases.
- CCL19 was expressed in 53% of tumor samples.
- Higher CCR6 expression correlated with shorter relapse-free survival.
- CCL19-expressing dendritic cells were associated with shorter relapse-free survival.
Takeaway
This study looked at how certain proteins in breast cancer cells might help the cancer spread, finding that some proteins are linked to worse outcomes.
Methodology
The expression levels of CCR6, CCR7, CCL19, CCL20, and CCL21 were evaluated using immunohistochemistry on paraffin-embedded tissue sections from 207 breast cancer patients.
Limitations
The study did not detect CCL20 expression in paraffin-embedded samples, which may limit the understanding of its role.
Participant Demographics
Median age was 56 years, with 48% having node-positive tumors and 84% having hormone receptor-positive tumors.
Statistical Information
P-Value
0.0316 for CCR6 and 0.042 for CCL19-expressing dendritic cells
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website