Effect of Isoflurane on Neutrophil Phagocytic Function During Pregnancy
1993
Effect of Isoflurane on Neutrophil Function During Pregnancy
Sample size: 18
publication
Evidence: moderate
Author Information
Author(s): Penny Clark, A. Joseph Layon, Patrick Duff
Primary Institution: University of Florida College of Medicine
Hypothesis
Does in vitro exposure to isoflurane impair the phagocytic response of neutrophils during pregnancy?
Conclusion
In vitro exposure to isoflurane for 90 minutes does not significantly alter the phagocytic capacity of neutrophils.
Supporting Evidence
- The mean percentage of phagocytizing neutrophils was similar between isoflurane-treated and control groups.
- Neutrophils exposed to isoflurane maintained their ability to phagocytize bacteria.
- Previous studies indicated that different anesthetics have varying effects on neutrophil function.
Takeaway
The study found that a common anesthetic used during pregnancy, isoflurane, does not stop white blood cells from fighting off germs.
Methodology
Neutrophils from 18 term patients were exposed to isoflurane and assessed for phagocytosis using flow cytometry.
Limitations
The study did not examine microbial killing by phagocytes.
Participant Demographics
Normal term patients aged 18 to 40 years in labor.
Statistical Information
Statistical Significance
NS
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