Neuroblastomas with Chromosome 11q Loss and Single Copy MYCN
Author Information
Author(s): Luttikhuis M E M Oude, Powell J E, Rees S A, Genus T, Chughtai S, Ramani P, Mann J R, McConville C M
Primary Institution: Department of Public Health & Epidemiology, University of Birmingham
Hypothesis
Does chromosome 11q loss correlate with poor outcomes in non-MYCN-amplified neuroblastomas?
Conclusion
Chromosome 11q loss is associated with a distinct group of neuroblastomas that have a poor prognosis.
Supporting Evidence
- Chromosome 11q loss was found exclusively in tumours without MYCN amplification.
- The 2-year event-free survival rate for 11q LOH cases was 30%.
- The event-free survival rate for MYCN-amplified cases was 34%.
- Cases without these abnormalities had a 100% event-free survival rate.
Takeaway
Some neuroblastomas have a change in chromosome 11 that makes them more likely to grow aggressively, even if they don't have a specific gene change that usually indicates a bad outcome.
Methodology
The study examined the correlation between clinical outcomes and loss of heterozygosity on chromosomes 3, 4, 11, and 14 in neuroblastoma patients.
Statistical Information
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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